The Complexity of Tobacco and Tobacco Smoke

Biological activity of tobacco smoke and tobacco smoke-related chemicals.

Exposure to whole cigarette smoke from reference cigarettes results in the prompt (peak activity is 6 hrs), but fairly weak (similar to 2 fold), induction of murine pulmonary microsomal monooxygenase activity. This activity can be detected by using as substrates either benzo(a)pyrene or ethoxyresorufin, and can be inhibited by treatment with cycloheximide or actinomycin D. Unlike the induction ...

Association between tobacco smoke and serum nitric oxide metabolites concentration

Introduction: Cigarette smoking affects nitric oxide production. The aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (NOx) concentration. Methods: Serum NOx concentration was measured by the Griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. Subjects were selected from participants of Tehran Lipid and Gl...

[Asthma and tobacco smoke].

Tobacco Smoke Filter Material

Environmental tobacco smoke epidemiology.

The Focus article "Double Exposure" [EHP 107:A196-A201 (1999)] mistakenly reported that a meta-analysis of epidemiology studies examining the relationship between exposure to environmental tobacco smoke (ETS) and human cancer was prepared for the review of ETS in consideration for listing in the National Toxicology Program (NTP) Report on Carcinogens. We would like to point out that the results...